The Histone Code and Beyond: New Approaches to Cancer Therapy by Shelley L. Berg

Description: The Histone Code and Beyond by Shelley L. Berger, O. Nakanishi, Bernhard Haendler Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book. Back Cover Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book. Table of Contents The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development.- Nucleosome Structure and Function.- The Role of Snf2-Related Proteins in Cancer.- Imitation Switch Complexes.- How Is Epigenetic Information on Chromatin Inherited After DNA Replication?.- Polycomb Silencing Mechanisms and Genomic Programming.- CpG Island Methylation and Histone Modifications: Biology and Clinical Significance.- Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces cerevisiae.- Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis.- Role of Ubiquitin-Like Proteins in Transcriptional Regulation.- Interplay of the SUMO and MAP Kinase Pathways. Long Description Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book. Feature Latest findings in the field of epigenetics, DNA and histone modifications Biochemical, genetic and structural aspects are presented by top specialists Details ISBN364242175X Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Year 2014 ISBN-10 364242175X ISBN-13 9783642421754 Format Paperback Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Subtitle New Approaches to Cancer Therapy Place of Publication Berlin Country of Publication Germany Edited by O. Nakanishi Series Ernst Schering Foundation Symposium Proceedings Affiliation Schering AG, Berlin Germany DEWEY 571.6 Short Title HISTONE CODE & BEYOND 2006/E Language English Media Book Series Number 57 Pages 215 Edition 2006th UK Release Date 2014-11-27 Publication Date 2014-11-27 Author Bernhard Haendler Edition Description 2006 ed. Alternative 9783540278573 Audience Professional & Vocational Illustrations XIV, 215 p. We've got this At The Nile, if you're looking for it, we've got it. 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